Titanium surface treatments have been introduced for many years in order to improve and accelerate osseointegration. The common element shared by the techniques is the research to obtain the formation of superficial cavities that allow a cellular rooting favorable to the development of the osteoblasts from which the neo-osteogenesis depends.

The treatments range from simple sandblasting to those obtained with lasers which allow the formation of suitable seats for size to accommodate the cells in a very precise manner. It is evident that the surface morphology does not influence this process in a metabolic way.
For this reason, the research presented has instead been directed in the direction of developing a substrate that performs a bi-active function.
So in addition to creating a Cellular site suitable for cellular LIE, the surface has been modified to intervene in a positive way on cellular metabolism.
In this way a surface with stimulating capacity was obtained both on osteoblastic cells and on undifferentiated mesenchymals.
The treatment introduced and patented by the author is based on the creation of an enhanced Ti oxide layer. The phenomenon of spontaneous passivation of Ti in the presence of O2 is known.
The decisive role of the interface thus created in the integration process is equally well known.
However, spontaneous passivation is not constant in both geometric and temporal sense. If not stimulated and provoked by method, it occurs unevenly and remains limited to a superficial micro-layer. With a combined treatment of exposure and immersion in a hyperoxidant agent under a strong source of ultraviolet light a uniform oxide layer was obtained more often and not altering the geometry of the cells welcoming the cells.


The research was carried out in collaboration for the physical and molecular part with the Department of Materials Science and Clinical Engineering of the Polytechnic of Turin and for the biological and cellular part with the Nobil Bio – research Institute of Portacomaro d ‘Asti.
Samples treated with simple sandblasting, ALS and photoactivated hyper-oxidation were considered.
The screws used only the type L produced by Implamed.
The surface physical characteristics were then analyzed by electronic scanning microscopy (SEM-EDS) and by infrared FTIR spectroscopy.